In forums are 1000 of different answers to question "What graphic setting are the best?". To get good answer you will have to understand how VSync, Antialiasing and Anisotropic filtering work. Read carefully following blog and according to your system and desires set yourself your graphic settings up.

Vertical Sync:
Vertical Synchronization (also called Vertical Sync, or simply VSync) is the synchronization of your graphics card and monitor's abilities to redraw the screen a number of times each second (measured in FPS or Hz).
If VSync is disabled (set to No), you may see some image "tearing" as your monitor and graphics card go slightly out of synchronization when the refresh rate exceeds the monitor's abilities, however your FPS can now exceed your monitor's refresh rate. You can have a refresh rate higher than 60Hz, it's just that your monitor will simply show some frames more than once. It is always recommended that you have as high a refresh rate as possible to ease eyestrain.
By turning VSync on your graphic card will synchronize every frame send to monitor with monitors ability and timing to show it in regular order.
1 more thing is here important : when VSync is on and you get ex. 60FPS you can use lower resolution and some programs (like re4ce or refreshclock) to get your monitor to have 100FPS without turning VSync off and avoiding image "tearing" and missynchronization of your graphic card and monitor.
Antialiasing:
Antialiasing is a method of smoothing the jaggedness of lines in 3D graphics. This setting has (up to) five options: Off, 2x, 4x, 8x and 16x. When set to Off, there is no additional Antialiasing used, unless you have forced Antialiasing enabled in your Graphics card's control panel. Antialiasing set to Off provides the fastest performance.
When set to 2x Antialiasing, this uses your graphics card to smooth out jagged lines at the cost of some FPS. Higher levels of Antialiasing will reduce FPS even more, but smooth out jaggedness considerably, particularly for distant objects. Note that if you have any level of Antialiasing enabled in your graphics card control panel, they will override these settings.
Anisotropic filtering:
Also referred to simply as Anisotropic (or AF) for short. This is a method which makes textures (the surfaces of all 3D objects) appear cleaner and crisper.
Raising the resolution of a game is one way of improving texture appearance, however textures receding into the distance may still become noticeably blurry and their finer features may become indistinguishable even at very high resolutions.
Anisotropic Filtering is used to enhance the details of textures, and to reduce the blurriness which occurs on textures that are further away.
The higher the level of Anisotropic Filtering applied, the clearer the textures will appear, but the greater the strain on your graphics card in filtering the image to produce the clearer representation of textures. Also, at very high levels of AF the clarity of distant textures may be unrealistically high.
I hope this has helped you and your game. Note that these guieds are simplified version of the proffesional guides, I didn't want to bother you with all other stuf, but these are the basics. If u want to learn some more search the net for guides, or msg me and I will help you in any way that I can.